Molecular characterization and expression of CD96 in red seabream (Pagrus major)

CD96 is a membrane-bound receptor discovered in humans 1992 that mainly present natural killer cells and T derived from haematopoietic performs immune functions. Based on the sequence of obtained red seabream (Pagrus major), phylogenetic analysis with other species, infections normal fish, Streptococcus iniae sea bream iridovirus (RSIV), expression was conducted using real-time polymerase chain reaction. Phylogenetic showed highest homology Sparus aurata, multiple confirmed conservation major domains between different fish species. Normal high results were head kidney, spleen, which are organs fish. High levels gills, liver, kidney day three after RSIV infection. After S. infection, gills liver one, spleen 12 hours. These show PmCD96 functions as an gene P. considered basic research case for fish’s hematopoietic organ system.